Dosage Information for Takhzyro: Details on forms, strengths, usage, and additional advice
News Article: Takhzyro Approved for Long-Term HAE Prevention in Children
A new treatment option for hereditary angioedema (HAE) in children has been approved. Takhzyro, a brand-name drug, is now prescribed for HAE prevention in children aged 2 years and older.
Takhzyro is a biologic and belongs to the class of kallikrein inhibitors. It is administered as a subcutaneous injection, which means it is given under the skin. The typical dosage for children is as follows:
- Children aged 2-6 years: 150 mg every 4 weeks
- Children aged 6-12 years: 150 mg every 2 weeks
- Children aged 12 years and older, and adults: 300 mg every 2 weeks
However, the dosage prescribed for an individual depends on their age, body response to Takhzyro, and the severity of their HAE.
Takhzyro works by inhibiting plasma kallikrein, which reduces bradykinin production responsible for HAE swelling episodes. This has been shown to be effective in both clinical and real-world studies, with the recommended dosage and administration being supported by data showing its long-term safety and efficacy in children as young as 2 years.
The medication is available as a single-dose prefilled syringe or a single-dose vial. It is meant for long-term treatment, and its safety and effectiveness will be determined by the doctor. It's important to note that Takhzyro starts working after the first dose, but it typically takes around 5 days to reach a high enough concentration in the body to start preventing HAE attacks.
It's crucial to follow the dosage prescribed by your doctor and never use more Takhzyro than prescribed, as this may lead to harmful effects or overdose. Takhzyro can be stored in the refrigerator and the solution should be allowed to warm up to room temperature before injection.
If you miss a dose, call your doctor or pharmacist. The medication can be self-injected into the abdomen or thigh. If you believe you've used too much Takhzyro, call your doctor right away or use America's Poison Centers at 800-222-1222 or its online tool.
Takhzyro is given as a subcutaneous injection every 2 weeks, typically. While there are other treatments for HAE mentioned in search results, such as sebetralstat (Orladeyo), they have different age indications or are for acute attacks rather than prevention and are not the same as Takhzyro.
Detailed instructions on how to use Takhzyro can be found on the manufacturer's website. Always consult with a healthcare professional familiar with your condition for personalized dosage and administration schedules.
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