Exploring Vraylar (Cariprazine): Its Adverse Reactions, Dosage, Purposes, and Additional Information

Exploring Vraylar (Cariprazine): Its Adverse Reactions, Dosage, Purposes, and Additional Information

Vraylar is a medication in capsule form, approved by the FDA, that's primarily used for various mental health conditions. It contains the active compound cariprazine, falling under the atypical (second-generation) antipsychotic drug category.

Vraylar is authorized for handling the following conditions in adults:

• Manic or mixed episodes in bipolar I disorder. With bipolar I disorder, people might experience episodes of mania (elevated mood) lasting at least 7 days or requiring hospital treatment. Manic episodes are severe, while a mixed episode is a mixture of mania and depression symptoms simultaneously. Vraylar is used for treating acute manic or mixed episodes, with "acute" referring to short-term treatment.
• Depressive episodes in bipolar I disorder. Vraylar can also manage depressive episodes in bipolar I disorder, which are often referred to as bipolar depression.
• Schizophrenia. Symptoms of schizophrenia include hallucinations (seeing or hearing things not present) and delusions (unsound beliefs.)
• Major depressive disorder (MDD). Often known as depression, MDD can lead to persistent low mood, lack of motivation, sleeping difficulties, and other issues. For MDD treatment, Vraylar is typically used together with an antidepressant. In this scenario, Vraylar is classified as an adjunctive treatment, meaning it's not used alone.

Drug specifics

• Form: Oral capsule
• Generic availability: No
• Prescription required: Yes
• Controlled substance: No
• FDA approval year: 2015

Vraylar side effects

Vraylar can induce mild to serious side effects. This text only lists some common side effects:

Some side effects may not present themselves immediately or after some time or after dose increases.

For further information on Vraylar's possible side effects, consult this article. You can also talk to your doctor or pharmacist for guidance on managing potential side effects.

Note: The FDA tracks medications' side effects after approval. If you experienced side effects with Vraylar, you can report them through MedWatch.

Mild side effects

Mild side effects of Vraylar may include:

• Unintended muscle movements (twitching, jerking, or movements of the head, neck, tongue, arms, or legs)
• Difficulty moving or slow movements
• Muscle rigidity
• Headache
• Dizziness
• Excessive saliva production
• Indigestion
• Constipation
• Weight gain†
• Feeling tired†
• Akathisia* (Experiencing an unpleasant, restless feeling that makes it difficult to sit or stand still.)
• Nausea† and vomiting

Most of these side effects might resolve within a few days or a couple of weeks. If they worsen or persist, contact your doctor or pharmacist.

This is a partial list of mild side effects from Vraylar. To learn about other mild side effects, speak with your doctor or pharmacist, or visit Vraylar’s prescribing information. Side effects may vary depending on the condition Vraylar is used to treat.

For more information on these side effects, see “Side effect details” below.

Serious side effects

While serious side effects are uncommon with Vraylar, they can still occur. Immediately contact your doctor if you encounter serious side effects. Dial 911 if you believe you're experiencing a medical emergency or if your symptoms seem life-threatening.

Serious side effects may include:

[Unnecessary details removed due to text length limitations]

• Postural Orthostatic Syndrome (decrease in blood pressure upon standing up). Symptoms can include:
  • feeling lightheaded or woozy when you rise too swiftly
  • syncope (fainting)
• Difficulties in regulating your body temperature, particularly in warm weather or during physical activity. Symptoms can include:
  • dry, warm skin
  • absence of sweating
  • heat exhaustion (overheating)
• Neuroleptic Malignant Syndrome (rare, severe reaction that may develop with antipsychotic medications). Symptoms can include:
  • high fever
  • sweating
  • muscle rigidity
  • drowsiness
  • confusion
  • rapid breathing
  • rapid heartbeat
• Low white blood cell count. Symptoms can include:
  • fever
  • sore throat
  • mouth sores (painful lesions within the mouth)
  • sore mouth and gums
• Elevated blood sugar and diabetes. Symptoms can include:
  • heightened hunger and thirst
  • increased urination frequency
  • weakness or fatigue
  • blurred vision
  • fruity-smelling breath
• High levels of fats, such as cholesterol and triglycerides, in your bloodstream.
• Seizures. Symptoms can include:
  • muscle convulsions
  • loss of consciousness and subsequent confusion
  • falling
• Difficulty swallowing, which may lead to aspiration (inhalation of food or liquid into your windpipe).
• Delayed reflexes and cognition, potentially rendering driving and machinery operation unsafe.
• Enhanced risk of falls due to side effects like dizziness, fatigue, and movement or coordination issues.
• Elevated risk of mortality in elderly individuals with psychosis due to dementia.
• Suicidal thoughts and behaviors.
• Allergic reaction.
• Tardive dyskinesia (chronic involuntary movements triggered by long-term medication use).

* Vraylar carries boxed warnings from the FDA with regard to these side effects. A boxed warning represents the FDA's strongest advisory, alerting medical professionals and patients of potentially hazardous drug effects.

Side effect details

You may be curious about the frequency of certain side effects with this medication or whether certain side effects are associated with it. Below, we've provided some information on various side effects this drug may or may not cause.

Allergic reaction

As with most medications, some people may experience an allergic reaction after taking Vraylar. The frequency of this occurrence is unknown.

Symptoms of a mild allergic reaction can include:

• skin rash
• itchiness
• flushing

A more serious allergic reaction is exceptionally rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under the skin, typically around the eyelids, lips, hands, or feet
• swelling of the tongue, mouth, or throat
• difficult breathing

If you encounter a severe allergic reaction to Vraylar, contact your doctor immediately. Dial 911 if your symptoms appear life-threatening or if you believe you're experiencing a medical emergency.

Weight gain

Weight gain is a potential side effect observed in clinical trials of Vraylar.

Your doctor will routinely monitor your weight throughout your Vraylar treatment. Should weight gain become a concern, discuss potential solutions with your healthcare provider.

Weight loss

Vraylar is not likely to cause significant weight loss. Weight loss was not reported in clinical trials of the drug.

Drowsiness

Vraylar may induce drowsiness in some individuals. Drowsiness was reported as a side effect in clinical trials of the drug.

If Vraylar makes you feel drowsy, refrain from driving or participating in other potentially dangerous activities. Should drowsiness prove bothersome, discuss alternative medications with your doctor.

Akathisia and tardive dyskinesia

Conditions referred to as akathisia and tardive dyskinesia may be associated with Vraylar use.

Akathisia

Akathisia was one of the most commonly reported side effects of Vraylar in clinical trials.

Akathisia manifests as an uncomfortable sensation of restlessness and a strong urge to move around, resulting in repetitive movements, particularly affecting the lower limbs.

Symptoms of akathisia can include:

• intense feelings of restlessness or discomfort
• restless movement, such as fidgeting or tapping the feet
• rocking back and forth while standing or sitting
• shifting weight from one foot to the other
• walking in circles
• pacing
• crossing and uncrossing your legs or swinging one leg while seated

should you develop symptoms of akathisia during Vraylar treatment, inform your doctor. In some cases, these symptoms may be alleviated by reducing the dosage of Vraylar. Your doctor may also prescribe an additional medication to help alleviate this side effect.

Tardive dyskinesia

The exact prevalence of tardive dyskinesia with Vraylar is uncertain, although the condition tends to be more common in females and older adults. The risk of developing tardive dyskinesia increases when using higher dosages for extended periods.

Uncontrollable, recurring body movements, often affecting the face, tongue, or jaw, but potentially impacting other body parts such as the arms or legs, characterize a condition known as tardive dyskinesia. This issue usually arises after prolonged usage of Vraylar, but can also develop post-cessation. In some instances, it may be permanent.

Tardive dyskinesia symptoms may encompass:

• repetitive lip smacks
• tongue twisting
• chewing motions
• puffing out cheeks
• grimacing
• erratic movements of the arms, legs, or torso

If you encounter symptoms of tardive dyskinesia while on Vraylar, it's crucial to inform your physician promptly. In some scenarios, symptoms might lessen through reduced medication doses. Alternatively, your doctor might prescribe an alternative medication to aid in alleviating tardive dyskinesia. If these solutions fail, your physician might propose a switch to a medication other than Vraylar.

* Gender and sexuality are multifaceted dimensions. In this context, the term “female” denotes the sex assigned at birth.

Nausea

A few individuals might experience nausea while ingesting Vraylar. Nausea was a reported adverse reaction in clinical trials of the medication.

Should nausea arise while using Vraylar, communicate your concerns with your doctor about potential management strategies.

Enhanced fatality risk in elderly adults with psychosis due to dementia

Elderly adults aged 65 and above with psychosis (loss of contact with reality) owing to dementia bear an elevated risk of mortality if they utilize antipsychotic medications such as Vraylar. Dementia is linked to challenges with cognition, memory, and communication.

Vraylar is not approved by the FDA for treating psychosis connected to dementia in older adults.

* Vraylar carries an FDA boxed warning regarding the heightened mortality risk in elderly adults with psychosis due to dementia. A boxed warning signifies the most serious warning from the FDA. For more information, refer to “FDA warnings” at the article's start.

Suicidal thoughts and behaviors

Those dealing with a mental health disorder, such as schizophrenia, bipolar disorder, or depression, face an increased risk of suicidal thoughts and behaviors. In certain instances, young children and adolescents might exhibit a greater risk of suicidal thoughts and actions while taking an antidepressant medication. Vraylar is an antipsychotic medication, yet it also boasts an antidepressant effect.

Clinical trials of various antidepressants have revealed a heightened risk of suicidal thoughts and behaviors in children and young adults under the age of 25 years. This risk peaks during the initial months of antidepressant therapy and after any dosage adjustments.

Your doctor will closely monitor you for indications of suicidal thoughts and behaviors during your Vraylar treatment.

While administering Vraylar, contact your doctor immediately if you:

• perceive your depression worsening
• experience sudden shifts in mood, thoughts, or behaviors
• harbor thoughts about death or self-harm
• attempt self-harm or suicide

Vraylar is unauthorized for use in children under the age of 17 years.

* Vraylar carries an FDA boxed warning regarding the increased risk of suicidal thoughts and behaviors. A boxed warning signifies the most serious warning from the FDA. For more information, refer to “FDA warnings” at the article's start.

Suicide prevention

If you're aware of an individual at immediate risk of self-harm, suicide, or harming another person:

• Directly question the individual: “Are you considering suicide?”
• Engage without judgment.
• Contact 911 or your local emergency number, or text TALK to 741741 to connect with a trained crisis counselor.
• Remain with the individual until professional assistance arrives.
• Safely remove any weapons, medications, or other potentially hazardous items, if feasible.

Should you or someone you know be grappling with thoughts of suicide, a prevention hotline can prove beneficial. The 988 Suicide and Crisis Lifeline is accessible 24 hours a day at 988. During a crisis, those with hearing loss can utilize their preferred relay service or dial 711 then 988.

Find additional links and local resources.

Vraylar dosage

The Vraylar dosage recommended by your physician will depend on several factors. These considerations may include:

• the condition you're utilizing Vraylar to treat and its severity
• your age
• any other medical conditions you might have
• other medications you're currently taking

Usually, your physician will initiated treatment with a low dosage. Then, they'll gradually adjust it to attain the optimal dosage for you. Your doctor will ultimately prescribe the minimal dosage needed to yield the desired result.

For additional details regarding Vraylar's dosage, peruse this article.

Initially, you generally commence your treatment with a 1.5mg dose on day 1. Following this, you proceed to a 3mg dose on day 2. Subsequently, your physician may incrementally escalate your daily dose as required, with a maximum of 6mg per day as the limit.

Dosage for Depressive Episodes in Bipolar I Disorder

To tackle episodes of depression in Bipolar I Disorder, the standard initial dose of Vraylar is 1.5mg daily. If necessary, your doctor may boost this dosage to 3mg daily starting from the 15th day of treatment.

Dosage for Schizophrenia

To manage schizophrenia, the typical dose of Vraylar ranges between 1.5mg and 6mg daily.

Usually, you initiate treatment with a 1.5mg dose on day 1. On day 2, your doctor may escalate the dose to 3mg. Subsequent dosage incrementation is contingent on your response, with a maximum of 6mg daily.

Dosage for Major Depressive Disorder (Depression)

For treating Major Depressive Disorder (MDD), commonly known as depression, the standard initial dosage of Vraylar is 1.5mg daily. If needed, your doctor may boost this dosage to 3mg daily starting from the 15th day of treatment.

For treating MDD, you'll utilize Vraylar in conjunction with an antidepressant. In such a scenario, Vraylar functions as an adjunctive treatment, not to be used isolatively. For more information, refer to the "Vraylar uses" section below.

Dosage Adjustments Based on Side Effects

Higher doses of Vraylar are associated with a higher incidence of side effects, which may worsen with increased dosage. (For more information on side effects, refer to the "Vraylar side effects" section above.)

However, Vraylar takes a significant amount of time to accumulate in your body. As a result, you may not experience some side effects until several weeks after initiating treatment or after a dose increase. Your healthcare provider will closely monitor you for side effects following the commencement of treatment and after any dose adjustments.

Should you develop bothersome side effects, your doctor may decrease your dose. While this may not alleviate the Vraylar side effects entirely, it may lessen their severity. However, due to Vraylar's long-lasting effects in the body, it may take at least a week for side effects to begin to improve.

Never adjust your Vraylar dose without your doctor's recommendation.

What if I miss a dose?

In case you miss a dose of Vraylar, take it as soon as possible, unless it's almost time for your next dose. If it's nearly time for your next dose, simply skip the missed dose. Then, take your next dose as scheduled. Do not take two doses to compensate for a missed dose.

To help ensure you do not miss a dose, consider utilizing a medication reminder. This could involve setting an alarm on your phone or downloading a reminder app. A medication timer may also be beneficial.

Will I need to use this drug long term?

For manic or mixed episodes of Bipolar I Disorder, you'll likely use Vraylar for a few weeks. Continue taking it as your doctor advises.

For other uses, Vraylar is intended as a long-term treatment. If you and your doctor determine that Vraylar is safe and effective for you, you'll likely continue taking it long term. It's crucial to adhere to your Vraylar dosage, even if you feel better. Discontinuing Vraylar use could lead to a resurgence of symptoms.

Vraylar uses

Prescription drugs, such as Vraylar, are approved by the Food and Drug Administration (FDA) to treat specific conditions. Vraylar may also be prescribed "off-label" for other conditions. Off-label use refers to a drug that's approved to treat one condition being prescribed to treat a different condition.

Vraylar for manic or mixed episodes in bipolar I disorder

Vraylar is FDA-approved to treat manic or mixed episodes of bipolar I disorder in adults. The drug is used for acute (short-term) treatment of these episodes.

Bipolar disorder is a mental health condition characterized by episodes of mania (elevated mood) and episodes of depression (low mood). Episodes of mania are also known as manic episodes, and episodes of depression are referred to as depressive episodes. In Bipolar I Disorder, manic episodes last at least 7 days or require hospitalization due to their severity.

Symptoms of manic episodes can include:

• feeling overly elated and exhilarated
• feeling restless, anxious, and jittery
• having racing thoughts
• talking excessively
• displaying exaggerated self-confidence
• exhibiting impaired judgment
• experiencing a reduced sense of risk
• participating in activities that may have damaging consequences

Individuals experiencing a manic episode may not recognize their behavior as unusual.

With severe manic episodes, you may also exhibit symptoms of psychosis. These include hallucinations (seeing or hearing things that aren't present) and delusions (beliefs that aren't grounded in reality).

To gain insights into the symptoms of depression that can surface during mixed episodes alongside the symptoms of mania, as previously mentioned, check out the section on "Vraylar for depressive episodes in bipolar I disorder" below.

Vraylar plays a crucial role in enhancing your mood, cognition, and behavior.

Efficiency for manic or mixed episodes

In clinical studies, Vraylar demonstrated effectiveness in managing acute manic or mixed episodes in individuals diagnosed with bipolar I disorder. For more information about these studies, refer to Vraylar's prescribing information.

Vraylar for depressive episodes in bipolar I disorder

The Food and Drug Administration (FDA) has approved Vraylar to treat depressive episodes in adults affected by bipolar I disorder.

Bipolar disorder is a mental health condition characterized by manic and depressive episodes. With bipolar I disorder, manic episodes last at least 7 days or require hospitalization due to their severity. For more details about manic episodes, head to the section on "Vraylar for manic or mixed episodes in bipolar I disorder" above.

During depressive episodes of bipolar I disorder, your mood takes a significant dive. Symptoms can include:

• Debilitating sadness or melancholy
• Feeling overwhelmed by hopelessness
• Unjustifiable guilt
• Nervousness
• Difficulty sleeping or experiencing excessive tiredness
• Lacking in energy
• Problems with memory
• Difficulty concentrating
• Easily annoyed or irritated

In severe depressive episodes, you may also experience psychosis symptoms, such as hallucinations and delusions.

Vraylar assists in enhancing your mood, cognition, and behavior.

Efficiency for depressive episodes

Vraylar showed effectiveness in treating depressive episodes in bipolar I disorder in clinical trials. Further information about these trials can be found in Vraylar's prescribing information.

Vraylar for schizophrenia

Vraylar has received FDA approval to treat schizophrenia in adults.

Schizophrenia is a chronic (long-term) mental health disorder that typically exhibits both positive symptoms and negative symptoms.

Positive symptoms, often referred to as psychosis symptoms, consist of thoughts and behaviors that were not present before the onset of schizophrenia. Symptoms may include hallucinations and delusions, as well as paranoia.

Negative symptoms are characterized by decreases in various thought and behavioral processes since schizophrenia began. Individuals may experience less energy, less interest in activities, and reduced ability to concentrate, remember, plan, and express emotions or communicate effectively.

Vraylar serves as an antipsychotic medication designed to aid in restoring your mood, cognition, and behavior.

Efficiency for schizophrenia

Vraylar demonstrated effectiveness in treating schizophrenia in multiple clinical trials. Additional information about these trials can be found in Vraylar's prescribing information.

Vraylar for major depressive disorder (depression)

Vraylar has received FDA approval to treat major depressive disorder (MDD) in adults. Commonly referred to as depression, this condition is thought to be caused by an imbalance of chemicals in the brain.

A healthcare professional may diagnose a person with MDD if they exhibit certain symptoms for most days for at least 2 weeks. Symptoms of MDD include:

• Persistent low mood
• Hopelessness
• Anxiety
• Difficulty sleeping or excessive tiredness
• Lack of energy
• Memory issues
• Attention span decreases
• Loss of motivation

For treating MDD, Vraylar is often used in conjunction with an antidepressant, such as fluoxetine (Prozac) or citalopram (Celexa). In such cases, Vraylar may be added to the treatment plan if antidepressants alone do not prove effective. Vraylar is then referred to as an adjunctive treatment, which means it is not used alone. Together, the medications assist in improving mood, cognition, and behavior.

Efficiency for MDD

Vraylar was found to be effective in treating MDD in clinical trials. Detailed information about these trials can be found in Vraylar's prescribing information.

Vraylar for other conditions

In addition to uses mentioned earlier, Vraylar may be employed off-label for various purposes. Off-label drug use refers to utilizing a drug approved for one purpose in a different context that has not been approved. You may wonder whether Vraylar can be used for certain other conditions. Information regarding possible uses for Vraylar in other scenarios is provided below.

Vraylar for autism (under investigation)

Vraylar has not yet been approved by the FDA to treat autism, which is also known as autism spectrum disorder (ASD). However, research is currently being conducted into this potential application.

ASD is a group of developmental disorders resulting from atypical brain development during childhood. People with ASD exhibit differences in communication, interaction, and behavior, which can impact learning ability, emotions, and impulse control.

Certain atypical (second-generation) antipsychotics have been approved for helping manage aggressive, impulsive, or self-harming behavior in individuals with ASD. Currently, approved drugs include aripiprazole (Abilify) and risperidone (Risperdal).

Further research is needed before it can be determined whether Vraylar is effective for ASD. Speak with your healthcare provider if you are interested in using Vraylar for the treatment of ASD.

Vraylar for bipolar II disorder (not an approved use)

Vraylar hasn't been given FDA approval for managing bipolar II disorder, which is also known as bipolar 2 disorder. It's not included in current U.S. treatment recommendations for bipolar disorder. However, these recommendations haven't been updated since 2005, and Vraylar was approved in 2015.

Bipolar disorder is a mental health condition characterized by periods of elevated mood (hypomania or mania) and periods of low mood (depression). When dealing with bipolar II disorder, individuals experience episodes of hypomania, which is less severe than a full-blown manic episode.

Research into treating bipolar II disorder is limited. More studies are required to determine whether Vraylar is effective for people with this condition.

If you have bipolar II disorder, it's essential to discuss available treatment options with your healthcare provider.

Vraylar and Children

Vraylar is not FDA-approved for treating schizophrenia, bipolar I disorder, or major depressive disorder (MDD) in children. The safety and effectiveness of Vraylar have not been thoroughly investigated in this age group.

Ongoing trials are examining the use of Vraylar to manage schizophrenia and depressive episodes connected to bipolar I disorder in children. At this point, it's unclear whether Vraylar is safe and effective for children suffering from these conditions.

If your child has schizophrenia, bipolar I disorder, or MDD, and you're curious about Vraylar or other treatment options, consult your child's healthcare provider.

Note: Vraylar has an FDA boxed warning regarding the increased risk of suicidal thoughts and behaviors. This risk applies to children and adults under 25 years of age. A boxed warning is the most serious warning issued by the FDA. For more information, see the "FDA warnings" section at the start of this article.

Vraylar cost and Coupons

Medication prices can vary widely, depending on your insurance plan, location, and the pharmacy you use.

Before approving coverage for Vraylar, your insurance company may need a prior authorization. This means your doctor and insurance provider will need to communicate about your prescription before the insurance company will cover the drug. They'll review the prior authorization request and determine whether the drug will be covered.

If you're unsure if you'll need a prior authorization for Vraylar, contact your insurance company.

For more about Vraylar and costs, refer to this article.

Drug Coupons

Explore the Optum Perks coupons below to save money on your Vraylar prescription.

You can also visit Optum Perks for price estimates of Vraylar using Optum Perks coupons. These estimates are based on the use of the Optum Perks coupons.

Note: Optum Perks coupons cannot be used with any insurance copays or benefits.

Optum Perks is related to Medical News Today.

Financial and Insurance Assistance

If you need financial help paying for Vraylar or require assistance understanding your insurance coverage, help is available.

Savings and payment assistance programs for Vraylar are available. For more information and to see if you're eligible for support, call 800-678-1605 or visit the drug website.

Generic Version

Vraylar is available as a brand-name medication only. A generic version is not currently available.

A generic drug is an exact replica of the active drug in a brand-name medication. Generics typically cost less than brand-name drugs.

Vraylar contains the active ingredient cariprazine.

Alternatives to Vraylar

Vraylar is an atypical (second-generation) antipsychotic used in managing schizophrenia, bipolar I disorder, and major depressive disorder.

Other drugs can treat your condition. Some may be a better fit for you than others. If you're interested in finding an alternative to Vraylar, talk to your doctor. They can advise you about other medications that could work well for you.

Note: Some of the drugs listed below are used off-label to treat these specific conditions. Off-label use is when a drug approved for one condition is prescribed for a different condition.

Alternatives for manic or mixed episodes in bipolar I disorder

Examples of other drugs that might be used to treat manic or mixed episodes in bipolar I disorder include:

• lithium
• divalproex (Depakote, Depakote ER)
• other atypical antipsychotics, such as:
  • aripiprazole (Abilify, Abilify MyCite)
  • asenapine (Saphris)
  • olanzapine (Zyprexa, Zyprexa Zydis)
  • quetiapine (Seroquel, Seroquel XR)
  • risperidone (Risperdal)
  • ziprasidone (Geodon)
• typical (first-generation) antipsychotics, such as chlorpromazine

Alternatives for depressive episodes in bipolar I disorder

Examples of other drugs that may be used to treat depressive episodes in bipolar I disorder include:

• lithium
• lamotrigine (Lamictal)
• selective serotonin reuptake inhibitor (SSRI) antidepressants, such as:
  • combination of fluoxetine (Prozac) with olanzapine (Zyprexa, Zyprexa Zydis)
  • fluoxetine/olanzapine (Symbyax)
• other atypical antipsychotics, like:
  • lurasidone (Latuda)
  • quetiapine (Seroquel, Seroquel XR)

Other options for schizophrenia treatment

Various other drugs can be utilized to manage schizophrenia, including:

• other atypical antipsychotics, such as:
  • aripiprazole (Abilify, Abilify MyCite, Abilify Asimtufii, Abilify Maintena, Aristada)
  • asenapine (Saphris)
  • brexpiprazole (Rexulti)
  • lurasidone (Latuda)
  • olanzapine (Zyprexa, Zyprexa Zydis, Zyprexa Relprevv)
  • paliperidone (Invega, Invega Sustenna, Invega Trinza, Invega Hafyera)
  • quetiapine (Seroquel, Seroquel XR)
  • risperidone (Risperdal, Risperdal Consta, Perseris, Rykindo, Uzedy)
  • ziprasidone (Geodon)
• typical (first-generation) antipsychotics, such as:
  • chlorpromazine
  • fluphenazine, fluphenazine decanoate
  • haloperidol, haloperidol decanoate
  • perphenazine

Additional therapies for major depressive disorder (MDD)

When dealing with major depressive disorder (MDD), often referred to as depression, Vraylar is typically administered with an antidepressant. In this context, Vraylar is used as an adjunctive treatment, meaning it is not taken alone.

Different medications can be utilized as adjunctive treatments in conjunction with antidepressants for MDD, such as:

• aripiprazole (Abilify, Abilify MyCite)
• brexpiprazole (Rexulti)

Vraylar and alcohol consumption

Consuming alcohol while taking Vraylar might increase your risk of certain side effects, including drowsiness, dizziness, and nausea.

Drinking alcohol can also exacerbate your depression symptoms.

If you consume alcohol, discuss this with your doctor to determine if it’s safe for you to do so while taking Vraylar.

Potential interactions with Vraylar

Vraylar may interact with various other medications and supplements. Different interactions can have different effects. Some interactions can interfere with how well a drug works, while others can increase side effects or make them more severe.

For more information about potential interactions with Vraylar, refer to this article.

Vraylar and other medications

Here are some medications that can interact with Vraylar. This list is not exhaustive.

Before starting Vraylar, communicate with your doctor and pharmacist about all prescriptive, over-the-counter, and additional drugs you are taking. It’s also important to share any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, consult your doctor or pharmacist.

Vraylar and certain infection-fighting drugs

Taking Vraylar with certain drugs used to fight infections can cause the level of Vraylar to build up in your body. This can raise your risk of side effects from Vraylar. (To learn more, see “Vraylar side effects” above.)

Examples of antimicrobial drugs that can increase the risk of side effects with Vraylar include:

• certain antibiotics, such as:
  • clarithromycin
  • erythromycin
• certain antifungals, such as:
  • ketoconazole
  • itraconazole (Sporanox)
  • posaconazole (Noxafil)
  • voriconazole (Vfend)
• certain medications for HIV, such as:
  • atazanavir (Reyataz)
  • cobicistat (Tybost)
  • ritonavir (Norvir)
  • nelfinavir (Viracept)

If you need to take one of these drugs with Vraylar, your doctor may have you take a lower dose of Vraylar.

Taking Vraylar with certain other drugs to fight infections can lower the level of Vraylar in your body. This could make Vraylar less effective, so you should not take these drugs with Vraylar.

Examples of these drugs include:

• rifabutin (Mycobutin)
• rifampin (Rifadin)
• rifapentine (Priftin)

If you’re taking any medication to fight an infection, discuss this with your doctor before starting Vraylar. They can adjust your treatment plan as needed.

Vraylar and certain seizure medications

Taking Vraylar with certain seizure medications could make Vraylar less effective. So you shouldn’t take these drugs with Vraylar.

Seizure suppressants that could potentially lessen Vraylar's efficacy include:

• carbamazepine (available as Carbatrol, Equetro, and Tegretol)*
• fosphenytoin (Cerebyx)
• phenobarbital
• phenytoin (sold as Dilantin and Phenytek)
• primidone (Mysoline)

*This drug is also commonly utilized off-label to manage bipolar disorder symptoms.*

If you're currently taking any of these medications, it's advised to consult your doctor before beginning Vraylar usage. They can adjust your treatment plan as required.

Vraylar and stimulants

Stimulants are primarily administered to manage attention deficit hyperactivity disorder (ADHD); however, misuse is prevalent. Misuse means using a drug contrary to a doctor's prescription. Common stimulants include:

• amphetamine/dextroamphetamine (offered as Adderall, Adderall XR, and Mydayis)
• lisdexamfetamine (Vyvanse)

People with mental health disorders, such as bipolar disorder or schizophrenia, should usually avoid stimulant usage. This is because stimulants can provoke new symptoms of psychosis or mania, and can worsen these conditions. For more information on symptom descriptions, see the "Vraylar uses" section outlined above.

Taking stimulants together with Vraylar could also elevate the chance of experiencing specific side effects, particularly involuntary muscle movements, such as tremors, twitches, or tics. (Learn more about these side effects by reading the "Vraylar side effects" section above.)

If you're using a stimulant, it's essential to consult your doctor prior to initiating Vraylar use. They can suggest the most suitable treatment options for you.

Vraylar and antidepressants

Antidepressants are sometimes prescribed to combat depression in individuals with schizophrenia or bipolar disorder. They may also be used concurrently with Vraylar.

Taking an antidepressant with Vraylar is generally acceptable, but the combination can lead to increased side effects, such as drowsiness, dizziness, and in rare cases, seizures. In addition, many antidepressants carry a "black box" warning for an enhanced risk of suicidal thoughts and behaviors in children and adults under 25 years old. Both Vraylar and many antidepressants possess this "black box" warning - issued by the Food and Drug Administration (FDA).

Utilizing both an antidepressant and Vraylar can also impact your capacity to make sound judgments, think clearly, or respond swiftly. Therefore, it's crucial to be aware of how your medications affect you before driving.

Examples of antidepressants that could potentially be taken with Vraylar include:

• bupropion (offered as Wellbutrin SR and Wellbutrin XL)
• duloxetine (Cymbalta)
• escitalopram (Lexapro)

If your doctor has prescribed you an antidepressant to use in conjunction with Vraylar, they'll closely monitor you for potential side effects. Discuss any concerns you might have about the side effects with your doctor.

*For additional information, see "FDA warnings" at the start of this article.*

Vraylar and mood stabilizers

Mood stabilizers are medications employed in the treatment of bipolar disorder to prevent future episodes of mania and depression. Your doctor may suggest commencing a mood stabilizer concurrently with Vraylar to manage an episode of mania or depression.

Taking a mood stabilizer together with Vraylar is typically acceptable; however, the combination may augment your risk of specific side effects, including drowsiness, dizziness, and confusion.

Using both a mood stabilizer and Vraylar can also affect your ability to make rational decisions, think clearly, or react promptly. It's thus essential to be aware of how your medications affect you before driving.

Examples of mood stabilizers that may be used in combination with Vraylar include:

• lithium
• divalproex (provided as Depakote and Depakote ER)
• lamotrigine (Lamictal)

If your doctor has prescribed you a mood stabilizer to take with Vraylar, they'll carefully monitor you for potential side effects. Discuss any concerns you might have about the side effects with your doctor.

Vraylar and anticholinergic drugs

Anticholinergic drugs are sometimes used to alleviate involuntary body movements that can be a side effect of Vraylar. Anticholinergic drugs are also sometimes used to treat COPD, asthma, and an overactive bladder.

If you utilize anticholinergic drugs in conjunction with Vraylar, you may be more likely to experience additional side effects. These can include constipation, dry mouth, blurred vision, and difficulties managing your body temperature.

Examples of anticholinergic drugs that may augment the risk of side effects when taken with Vraylar include:

drugs commonly used for chronic obstructive pulmonary disease (COPD) or asthma, such as: + acclaimidine (Tudorza Pressair) + tiotropium (Spiriva)certain medications for an excessive bladder issue or incontinence, such as: + tolerodine (Detrol, Detrol LA) + darifenacin + solifenacin (Vesicare, Vesicare LS) + fesoterodine (Toviaz)certain medications for uncontrollable body movements, such as: + benzotropine + trihexyphenidyl + orphenadrine

If you need to take one of these medications alongside Cariprazine, your doctor will closely monitor you for any side effects, including blurred vision or a dry mouth. Be cautious to avoid excessive heat.

Cariprazine and herbs and supplements

Use of St. John’s wort with Cariprazine might decrease the level of Cariprazine in your body. As a result, do not use St. John’s wort with Cariprazine, as it could reduce Cariprazine's effectiveness.

Cariprazine and caffeine and foods

No specific foods have been reported to interact with Cariprazine. If you have any questions about eating particular foods with Cariprazine, consult your doctor.

Cariprazine and caffeine

Caffeine is not known to interact with Cariprazine. Caffeine is a stimulant found in various foods and beverages, such as coffee, tea, and energy drinks. (For additional information on how stimulants may affect Cariprazine, see the “Cariprazine and stimulants” section above.)

However, caffeine may impact your ability to fall asleep, possibly leading to mood changes if you have bipolar I disorder.

If you have concerns regarding caffeine consumption while taking Cariprazine, talk with your doctor.

Cariprazine and grapefruit juice

Consumption of grapefruit or grapefruit juice can increase the levels of various medications in your blood. This may heighten the risk of side effects from the medication. In theory, consuming grapefruit or grapefruit juice with Cariprazine could elevate the level of Cariprazine in your body. However, there have not been any studies on this.

If you wish to consume grapefruit or drink grapefruit juice with Cariprazine, consult your doctor about the safety of this for you. If you experience an increase in side effects with the combination, avoid consuming grapefruit products with Cariprazine in the future.

Common questions regarding Cariprazine

Here are responses to some often-asked questions about Cariprazine.

Can Cariprazine be used for anxiety?

It's highly unlikely. Cariprazine, an antipsychotic drug, is not specifically designed for treating anxiety disorders. Anxiety disorders are usually treated with medications such as benzodiazepines, specific antidepressants, or beta-blockers.

If treatments like these don't work, antipsychotics, other than Cariprazine, might be used occasionally. For instance, a review of studies found quetiapine (Seroquel, Seroquel XR) to be effective for treating generalized anxiety disorder. However, because antipsychotics can cause some serious side effects, other anxiety treatments are generally more suitable.

Remember that if anxiety is one of the symptoms of your schizophrenia, bipolar I disorder, or major depressive disorder, it may improve with Cariprazine treatment.

If you have anxiety, consult your doctor about the appropriate treatments for you.

Is Cariprazine an SSRI?

No, Cariprazine is not an SSRI, which stands for selective serotonin reuptake inhibitor. SSRIs are a specific type of antidepressant medication.

Cariprazine is an atypical (second-generation) antipsychotic medication.

Does Cariprazine cause sexual side effects?

No. Cariprazine, an antipsychotic medication, is not known to cause sexual side effects. These problems were not reported in clinical trials for the drug. However, sexual problems are known to occur with other antipsychotics. And sexual problems can also be associated with the conditions that Cariprazine treats.

Discuss sexual problems with your doctor if they concern you. They may be able to recommend a compatible treatment.

Why do I have to avoid excessive heat while taking Cariprazine?

Cariprazine can reduce sweating and affect how your body regulates its core temperature. The drug makes it more challenging for your body to cool down if you get too hot. This is particularly problematic in hot weather or during exercise. If you cannot cool down properly, you may develop heatstroke (overheating).

While using Cariprazine, avoid strenuous exercise and wear too much warm clothing. Be sure to drink plenty of water to avoid dehydration (losing too much fluid). And in hot weather, stay in a cool place avoiding direct sunlight.

Discuss additional strategies for avoiding excessive heat during your Cariprazine treatment with your doctor.

Will I be able to drive during my Cariprazine treatment?

Most likely. The majority of people are able to drive while taking Cariprazine. However, be aware that Cariprazine can make some people feel drowsy. And the drug could impact your ability to make decisions, think clearly, or react quickly.

Before you get behind the wheel with Vraylar, make sure you're well-aware of its effects. Drive only if you can do so safely.

Vraylar and Competitors

You might be curious about how Vraylar stacks up against other medications prescribed for similar conditions. Here, we explore the similarities and differences between Vraylar and Abilify.

Note: Abilify is marketed under various brand names, including Abilify, Abilify MyCite, Abilify Maintena, and Abilify Asimtufii. The approved uses for these forms of the drug can vary, so discuss any questions with your physician. This section focuses on the plain Abilify form.

Components

Vraylar uses cariprazine as its active ingredient, whereas Abilify relies on aripiprazole.

Applications

Vraylar is approved to treat:

• manic and mixed episodes in adults with bipolar I disorder
• depressive episodes in bipolar I disorder in adults
• schizophrenia in adults
• major depressive disorder (MDD) in adults, also known as depression

Abilify is approved to treat:

• manic and mixed episodes in adults and children aged 10 years and over with bipolar I disorder
• MDD in adults and children aged 13 years and over
• schizophrenia in adults and children aged 13 years and over
• irritability associated with autism spectrum disorder in children aged 6 years and older
• Tourette syndrome in children aged 6 years and older

For treating MDD, Vraylar and Abilify are administered along with an antidepressant. In such cases, they are referred to as adjunctive treatments, meaning they are not used in isolation.

Dosage and Administration

Vraylar comes in the form of an oral capsule, which should be taken once per day.

Abilify is available as an oral tablet that should also be taken once daily.

Side Effects and Risks

Vraylar and Abilify share some side effects, while others may differ. Below you'll find examples of both types of side effects.

Mild Side Effects

This list contains up to 10 common mild side effects that can occur with both Vraylar and Abilify (when used separately):

• headache
• indigestion
• involuntary muscle movements, such as twitching, jerking, or twisting movements of the head, neck, tongue, arms, or legs
• muscle stiffness
• increased saliva production
• akathisia (due to a feeling of restlessness and inability to sit or stand still)
• nausea and vomiting
• drowsiness
• constipation
• weight gain

Serious Side Effects

These lists provide examples of serious side effects that may occur with Vraylar, with Abilify, or with both drugs:

• Can occur with Vraylar:
  • no unique serious side effects
• Can occur with Abilify:
  • compulsive behaviors, such as intense, uncontrollable urges for gambling, shopping, or overeating
• Can occur with both Vraylar and Abilify:
  • increased risk of death in older adults with psychosis due to dementia*
  • suicidal thoughts and behaviors*
  • allergic reaction
  • orthostatic hypotension (drop in blood pressure when getting up)
  • risk of falls due to side effects like dizziness, sleepiness, and problems with movement or coordination
  • slowed reflexes and thinking, which may affect the safety of driving and operating machinery
  • low white blood cell count
  • trouble managing body temperature, particularly in hot weather or while exercising
  • problems swallowing, which could lead to aspiration (breathing in food or liquid into your airway)
  • high blood sugar and diabetes
  • high levels of fats like cholesterol and triglycerides in your blood
  • seizures
  • tardive dyskinesia (involuntary body movements developed after long-term use of the medication)
  • neuroleptic malignant syndrome (rare, severe reaction often associated with antipsychotic drugs)

* Both Vraylar and Abilify have boxed warnings from the FDA regarding these side effects. A boxed warning is the strongest warning the FDA requires. For more information, see “FDA warnings” at the beginning of this article.

Effectiveness

Although Vraylar and Abilify are intended for different approved uses, they are both employed to treat manic and mixed episodes of bipolar I disorder, schizophrenia, and MDD (when used in combination with an antidepressant).

Unfortunately, these drugs haven't been directly compared in clinical trials. However, both Vraylar and Abilify have been shown to be effective in treating these conditions.

Both drugs are recommended as treatment options for schizophrenia in guidelines from the American Psychiatric Association.

If you're considering Vraylar or Abilify, discuss your options with your physician.

The expenses of Vraylar and Abilify will change based on your treatment plan. The actual fee you'll be charged for either medication depends on your insurance coverage, your location, and the pharmacy you use. You can check out Optum Perks* for approximate prices of Vraylar and Abilify.

Both Vraylar and Abilify are proprietary drugs with no generic variants for Vraylar presently. Generic formulations of Abilify are available under the name aripiprazole. Generally, brand-name medicines are more costly than generics.

* Optum Perks is a subsidiary site of Medical News Today.

Vraylar vs. Luvox

Like Abilify (above), the drug Luvox has uses similar to those of Vraylar. Here's a comparison of how Vraylar and Luvox differ and resemble each other.

Components

Vraylar contains the active drug cariprazine, while Luvox contains the active drug fluoxetine.

Uses

Vraylar is approved to treat:

• manic and mixed episodes of bipolar I disorder in adults
• depressive episodes of bipolar I disorder in adults
• schizophrenia in adults
• major depressive disorder (MDD), often called depression, in adults*

Luvox is approved to treat:

• obsessive-compulsive disorder (OCD) in adults and children ages 6 years and older
• bulimia nervosa in adults
• premenstrual dysphoric disorder (PMDD) in adults
• panic disorder with or without agoraphobia in adults

* For treating MDD, Vraylar is taken with an antidepressant. In this situation, Vraylar is considered an adjunctive treatment, meaning it is not used alone. For treating depressive episodes of bipolar I disorder, doctors may suggest adults take Luvox either alone or with lithium or valproate.

Drug types and usage

Vraylar comes as an oral capsule, while Luvox comes as an oral capsule or tablet. You’ll likely take Vraylar or Luvox once per day.

Adverse effects and threats

Vraylar and Luvox both contain an atypical (second-generation) antipsychotic drug. They can cause some similar side effects, yet some different ones as well. Below are examples of these side effects.

Less serious side effects

These lists contain up to 10 of the most common mild side effects that can occur with Vraylar, with Luvox, or with both drugs (when taken individually).

• Can occur with Vraylar:
  • constipation
• Can occur with Luvox:
  • no unique side effects
• Can occur with both Vraylar and Luvox:
  • indigestion
  • involuntary muscle movements, such as twitching, jerking, or twisting movements of your head, neck, tongue, arms, or legs
  • muscle stiffness
  • increased production of saliva
  • akathisia (feeling uncomfortably restless and unable to sit or stand still)
  • feeling sleepy
  • weight gain
  • nausea and vomiting
  • diarrhea
  • anxiety

More severe side effects

These lists contain examples of severe side effects that can occur with Vraylar, with Luvox, or with both drugs (when taken individually).

• Can occur with Vraylar:
  • no unique severe side effects
• Can occur with Luvox:
  • suicidal thoughts and behaviors*
  • serotonin syndrome (a potentially serious condition when serotonin levels become too high)
• Can occur with both Vraylar and Luvox:
  • increased risk of death in older adults with psychosis due to dementia*
  • tardive dyskinesia (involuntary body movements that develop after you’ve taken the medication for a long time)
  • neuroleptic malignant syndrome (a rare, severe reaction that can occur with antipsychotic drugs)
  • high blood sugar and diabetes
  • high levels of fats such as cholesterol and triglycerides in your blood
  • low white blood cell count
  • orthostatic hypotension (drop in blood pressure when getting up)
  • problems managing your body temperature, especially in hot weather or when exercising
  • seizures
  • trouble swallowing, which could lead to aspiration (breathing food or liquid into your airways)
  • risk of falls due to side effects such as dizziness, sleepiness, and problems with movement or coordination
  • slowed reflexes and thinking, which could make driving and operating machinery unsafe
  • allergic reaction

* Both Vraylar and Luvox have boxed warnings from the FDA regarding these side effects. A boxed warning is the strongest warning the FDA requires. For more information, see “FDA warnings” at the beginning of this article.

If you're considering using Vraylar or Latuda, it's essential to discuss with your doctor which one would suit you best.

Costs

The cost you'll pay for Vraylar or Latuda is contingent upon your insurance plan, location, and pharmacy. You can explore Optum Perks* for price estimates of Vraylar and Latuda.

Vraylar and Latuda are brand-name medications. A generic form of Latuda called lurasidone has been authorized by the FDA, while no generic version of Vraylar is presently available. Generics generally are more cost-effective than brand-name medications.

* Optum Perks is a sister site of Medical News Today.

Vraylar vs. Rexulti

Vraylar and Rexulti are both atypical (second-generation) antipsychotics, which help enhance your mood, thinking, and behavior. However, these two drugs have some notable distinctions.

Vraylar exists as an oral capsule containing the active ingredient cariprazine. It's prescribed to treat:

• manic or mixed episodes of bipolar I disorder in adults
• depressive episodes of bipolar I disorder in adults
• schizophrenia in adults
• major depressive disorder (MDD), commonly known as depression, in adults*

Rexulti comes as an oral tablet containing the active ingredient brexpiprazole. Rexulti can be prescribed for:

• MDD in adults*
• schizophrenia in adults and children 13 years and older
• agitation in adults resulting from dementia due to Alzheimer’s disease

Discuss with a pharmacist or your doctor for details regarding how Vraylar and Rexulti compare.

* For treating MDD, Vraylar and Rexulti are taken in combination with an antidepressant. In this situation, these drugs are referred to as adjunctive treatments, meaning they are not used alone.

Vraylar vs. Seroquel

Vraylar and Seroquel possess similarities, but they also have differences. Both are atypical (second-generation) antipsychotic drugs, which help improve your mood, thinking, and behavior.

Vraylar comes as an oral capsule and contains the active ingredient cariprazine. It's prescribed to treat:

• manic or mixed episodes of bipolar I disorder in adults
• depressive episodes of bipolar I disorder in adults
• schizophrenia in adults
• major depressive disorder (MDD), commonly known as depression, in adults*

Seroquel comes as an oral tablet containing the active ingredient quetiapine. It's prescribed to treat:

• manic or mixed episodes of bipolar I disorder in adults† and children ages 10 and older
• depressive episodes of bipolar I disorder in adults
• schizophrenia in adults and children ages 13 years and older

Seroquel also provides an extended-release tablet called Seroquel XR. The conditions Seroquel XR is authorized to treat vary from those of Seroquel. “Extended release” indicates that the drug is gradually released into your body over a lengthy period.

Your doctor or pharmacist can provide more information about the similarities and differences between these drugs.

* For treating MDD, Vraylar is taken in combination with an antidepressant. In this situation, Vraylar is referred to as an adjunctive treatment, meaning it is not used alone.† For treating manic or mixed episodes of bipolar I disorder, adults may take Seroquel either alone or with lithium or divalproex.

Vraylar withdrawal and dependence

It's unlikely that you'll experience withdrawal symptoms or side effects after halting Vraylar treatment. Withdrawal symptoms are side effects that manifest if you stop taking a drug that your body has become dependent on. And when you're dependent on a drug, your body requires the drug to feel as usual.

However, if you cease taking Vraylar, your symptoms of the condition might reappear. So, it's recommended not to discontinue using Vraylar without consulting your doctor first. If you and your doctor agree that it's appropriate for you to stop utilizing Vraylar, then they will elucidate the process for doing so.

It's significant to note that newborns of individuals who take an atypical (second-generation) antipsychotic in the last 3 months of pregnancy can be at risk of withdrawal symptoms. (Vraylar is an atypical antipsychotic.) To learn more, see the “Vraylar and pregnancy, breastfeeding, and birth control” section below.

Vraylar misuse (also called abuse)

Vraylar hasn’t been investigated for the possibility of drug misuse. Misuse refers to using a drug in a manner other than how a doctor prescribes it. Misuse of Vraylar can lead to serious side effects. (See “Serious side effects” in the “Vraylar side effects” section above for details.) Always use the medication strictly as prescribed by your doctor, and never provide Vraylar to anyone else.

Neurotransmitters are organic substances that transmit signals between neurons and various other cells within the body. Dopamine and serotonin play a crucial role in transmitting messages within the brain, influencing factors such as mood, thought processes, perception, and behavior.

An imbalance in dopamine and serotonin levels can lead to symptoms associated with various mental health conditions, including depression, mania, and psychosis. Symptoms of psychosis may include hallucinations (perceiving things that aren't present), delusions (believing in untrue concepts), and paranoia.

What Cariprazine (Vraylar) does

Cariprazine, also known as Vraylar, is a type of medication classified as an atypical (second-generation) antipsychotic. These medications work by adjusting the function of dopamine and serotonin in the brain, although the exact mechanism of action of Cariprazine is not fully understood.

Cariprazine is effective in reducing symptoms of psychosis, such as hallucinations, delusions, and paranoia. Additionally, it helps manage symptoms of mania, including intense agitation, racing thoughts, and hyperactivity. Cariprazine has also been shown to improve mood, alleviating feelings of severe sadness, hopelessness, and guilt that are often associated with depression.

In addition to these primary effects, Cariprazine can improve other symptoms associated with the conditions it is used to treat, such as anxiety, sleep disturbances, and a lack of energy. It can also help with cognitive difficulties, such as problems with memory, concentration, and communication.

Time to Effect and Elimination

Cariprazine begins working within a few days of initiation of treatment. Symptoms such as hallucinations and agitation typically improve first, while other symptoms may take longer to reduce, requiring several weeks for Cariprazine to reach its full potential.

It is essential to continue taking Cariprazine as prescribed by your doctor, even if the improvements seem minimal at first, to maximize its efficacy.

Cariprazine Elimination and Half-life

Cariprazine has a half-life of approximately one week. The half-life of a drug is the time it takes for its concentration in the body to decrease by half. Following cessation of Cariprazine use, the drug level in the body decreases gradually, with a half-life of approximately one week. At the end of this period, the drug level is reduced to half its original concentration. This process continues, with the drug level decreasing to a quarter after another week, to an eighth after a third week, and so on.

Generally, the complete elimination of the drug from the body is assumed to take around 5.5 half-lives, which would mean approximately 5.5 weeks for Cariprazine. However, trace amounts of the drug may remain detectable in blood tests for a longer period.

Cariprazine Overdose

Adhering to your doctor's recommended dosage of Cariprazine is crucial to avoid unwanted side effects or overdose.

Excessive Cariprazine intake

If you suspect that you have taken an excessive amount of Cariprazine, consult your doctor or healthcare professional immediately. Alternatively, you can contact the American Poison Control Center at 800-222-1222 or use their online tool. In case of severe symptoms, contact emergency services (dial 911 or visit the nearest emergency room) without delay.

Cariprazine and Pregnancy, Breastfeeding, and Birth Control

Pregnant women, nursing mothers, and those using birth control methods should consider the safety of Cariprazine for their personal circumstances.

You can find further information here. If you have additional questions, consult your healthcare provider.

Cariprazine Administration

Take Cariprazine as directed by your doctor or healthcare provider.

Timing of Administration

Administration once daily is usually recommended. Try to maintain a regular dosing routine by taking Cariprazine at the same time each day. Choose a convenient time for you, and stick to that schedule to facilitate medication adherence.

To aid memory, consider using a medication reminder such as setting an alarm on your phone or downloading a reminder app. A medication timer may be helpful, as well.

Cariprazine with Food

Cariprazine can be taken with or without food.

Crushing, Splitting, or Chewing Cariprazine

Swallow Cariprazine capsules whole. Drinking water can make this process easier if needed. Consult your doctor or pharmacist for advice if you are having difficulty swallowing Cariprazine capsules.

Cariprazine Precautions

Cariprazine has multiple precautions associated with its use.

FDA Warnings

Cariprazine carries certain boxed warnings from the FDA, serving as a serious alert for healthcare providers and patients regarding drug effects that may be harmful.

Increased risk of death in older adults with psychosis due to dementia. Older individuals with dementia may develop psychosis (loss of contact with reality). In some instances, antipsychotic medications like Cariprazine may increase the risk of death in this age group. The FDA has not approved Cariprazine for treating psychosis associated with dementia in older adults.

Thoughts of self-harm and suicidal tendencies. In certain instances, some antidepressant drugs might augment the likelihood of self-harm thoughts and actions in people beneath the age of 25 years. Vraylar is a psychoactive medication, but it also has antidepressant qualities when utilized for depression in instances of bipolar I disorder or major depressive disorder (commonly referred to as depression). During your use of Vraylar, your doctor may regularly monitor you for any signs of self-harm thoughts and actions. Vraylar is not approved for use in individuals aged 17 years and under.

Additional precautions

Before starting Vraylar, discuss your medical history with your doctor. Vraylar may not be suitable for you if you have certain medical conditions or factors affecting your health. These include:

• Allergic reaction. If you've had an allergic reaction to Vraylar or any of its components, you should avoid taking Vraylar. Consult your doctor about alternative medications that would be more suitable for you.
• Renal disorders. Vraylar hasn't been tested in individuals with severe renal issues. Speak with your doctor about whether Vraylar is appropriate for you if you have kidney problems.
• Hepatic problems. Vraylar hasn't been tested in individuals with severe liver issues. If you have liver problems, discuss with your doctor whether Vraylar is a suitable option for you.
• Advanced age. Individuals aged 65 years or older may have a higher risk of certain side effects with Vraylar. These include dizziness upon standing, falls, tardive dyskinesia, and issues managing body temperature. Older adults are usually given a lower dose of Vraylar to minimize any potential risks from the drug. Your doctor will monitor you for side effects.
• Diabetes. Vraylar can induce elevated blood sugar levels and diabetes. If you already have diabetes, taking Vraylar can make your blood sugar harder to manage. Discuss with your doctor whether Vraylar is suitable for you. If you do take Vraylar, your blood sugar may need to be checked more frequently than usual. If your blood sugar becomes too high, your doctor may need to increase the dosage of your diabetes medication.
• High or low blood pressure. Vraylar may affect your blood pressure. If you have problems with blood pressure, Vraylar may exacerbate these issues. Inform your doctor if you have a history of blood pressure issues. They can help you decide whether Vraylar is suitable for you.
• High cholesterol or triglyceride levels. Vraylar may raise the levels of fats called cholesterol and triglycerides in your blood. If you already have elevated levels of these fats, Vraylar could raise them further. While taking Vraylar, your doctor will regularly order blood tests to check your cholesterol and triglyceride levels. If the levels rise too high, you may require treatment for them.
• Low white blood cell count. Vraylar can decrease your white blood cell count. You may be at increased risk of this if a medication has decreased your white blood cell count in the past. And if your white blood cell count is already low, Vraylar could further lower it. In both circumstances, your doctor will regularly order blood tests to check your white blood cell levels while taking Vraylar. If your white blood cell count falls too low, you may need to stop the medication.
• Dehydration. If you become dehydrated while taking Vraylar, this can increase your risk of certain side effects. These include dizziness upon standing and issues managing body temperature. To avoid dehydration, make sure to drink plenty of water while taking Vraylar. This is especially important during hot weather and when exercising.
• Cardiovascular disease or stroke. Vraylar can temporarily decrease your blood pressure if you get up too quickly. This could be dangerous if you have a history of stroke or heart problems, such as angina, heart attack, or heart failure. Vraylar hasn't been studied in individuals with unstable heart disease or in individuals who have recently had a heart attack. If you have a history of any of these problems, talk with your doctor about whether Vraylar is suitable for you. If you do take Vraylar, inform your doctor if you feel dizzy or faint while using it.
• Epilepsy or previous seizures. Vraylar can sometimes cause seizures. You're more likely to have seizures with Vraylar if you have epilepsy or you've had seizures in the past. Talk with your doctor about whether Vraylar is a suitable choice for you.
• Pregnancy. Discuss the risks and benefits of taking Vraylar during pregnancy with your doctor. For more information, see the “Vraylar and pregnancy, breastfeeding, and birth control” section above.
• Breastfeeding. It's not known whether Vraylar passes into breast milk. For more information, see the “Vraylar and pregnancy, breastfeeding, and birth control” section above.

Note: For more information about the potential negative effects of Vraylar, see the “Vraylar side effects” section above.

Upon obtaining Vraylar from the pharmacy, they will affix an expiration date to the bottle's label. Typically, this date is set a year from the medication's dispensation.

This expiration date is essential to ensure the medication maintains efficacy within that period. The FDA's guidelines primarily urge avoiding the utilization of expired medications. If you have surplus medication that has surpassed its expiration date, consult your pharmacist on the correct disposal method.

Preservation

The length a medication maintains its potency can depend on various factors, such as storage methods and conditions.

Vraylar capsules should be stored at room temperature (between 68-77°F or 20-25°C) in a secure, tightly sealed container, far from light. Avoid storing this medication in damp or wet environments, like bathrooms.

Disposal

Should you no longer require Vraylar and possess leftover medication, safely disposing of it is crucial. This aids in preventing unintentional ingestion by individuals, including children and pets. Additionally, it aids in preserving the environment from harm by the drug.

This article offers valuable recommendations on medication disposal. You can also ask your pharmacist for advice on disposing of your medication.

Disclaimer:

Medical News Today has made every effort to ensure that the information presented is factually correct, comprehensive, and up-to-date. However, this article should not be considered a substitute for the expertise and advice of a licensed healthcare professional. Always consult your doctor or another healthcare professional before taking any medication. The drug information supplied herein is subject to change and should not be considered a comprehensive guide to all potential uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. The lack of details provided for a particular drug does not imply that the drug or drug combination is safe, effective, or beneficial for all patients or uses.

1. Vraylar is primarily used for managing various mental health conditions, including manic or mixed episodes in bipolar I disorder, depressive episodes in bipolar I disorder, schizophrenia, and major depressive disorder (MDD).
2. It's essential to adhere to your doctor's prescribed dosage and schedule, as skipping or forgetting doses may exacerbate symptoms or reduce the medication's effectiveness.
3. If you miss a dose of Vraylar, consult your healthcare provider for advice on how to manage it, as timing and dosage adjustments may be necessary.
4. In general, missing a single dose is unlikely to have significant consequences, but it's crucial to stay consistent with your medication regimen for optimal treatment outcomes.

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