Interactions of Zetia with other medications, alcohol, and various substances
Zetia, a popular brand-name oral tablet, is often prescribed to adults and some children for managing high cholesterol levels. However, it's essential to understand potential interactions with other medications, food, and health conditions before starting treatment.
Zetia isn't known to interact with any lab tests, vaccines, or specific reports of food, herbs, or vitamins. However, it can interact with other drugs, such as cyclosporine, fibrates (e.g., fenofibrate, gemfibrozil), and bile acid sequestrants (e.g., cholestyramine, colesevelam, colestipol).
One crucial drug interaction to be aware of is the combination with statins, especially fluvastatin. This combination may increase the risk of liver damage and rhabdomyolysis, a serious muscle condition.
Other potential interactions include Entresto (sacubitril/valsartan), antiviral drugs used with rosuvastatin (a related cholesterol medication), and some antacids. While not direct Zetia interactions, similar cholesterol medications interact with antivirals such as those used in Paxlovid, Harvoni, and others—suggesting caution when Zetia is coadministered with antiviral regimens.
It's also important to note that taking Zetia with CBD (cannabidiol) or cannabis products has not been specifically reported to interact with Zetia. However, your doctor will likely not prescribe Zetia if you have moderate or severe liver problems.
If you have a liver problem, Zetia may build up in your body, raising your risk of side effects from the medication. Taking Zetia with cyclosporine can also raise your risk of side effects from both medications.
An interaction occurs when one substance causes another substance to have a different effect than expected. Therefore, it's crucial to inform your doctor and pharmacist about all medications you take, including prescription, over-the-counter, and other drugs, before starting treatment with Zetia.
Taking Zetia could also make your liver problem worse, especially if you take Zetia with a statin medication. If you have questions about drug interactions, consult your doctor or pharmacist for personalized advice and monitoring. Always remember that your healthcare provider is the best source of information regarding your specific situation.
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