Research: Inoculation Safeguards against Cancer-Linked HPV Variants
In a groundbreaking study published in the journal "Eurosurveillance", researchers from Denmark have provided robust evidence supporting the effectiveness of HPV vaccination in reducing cervical cancer cases. The study, conducted over a period of seven years and analysing around 17,000 Pap smears from 8,659 women aged 22 to 30, has shown that HPV types 16 and 18 have been nearly completely eliminated in Denmark since the country began vaccinating girls in 2008.
Before the HPV vaccination program started in Denmark, high-risk HPV types 16 and 18 were responsible for approximately 74% of cervical cancers. The study's results indicate a significant reduction in HPV prevalence and persistent infection among vaccinated women, suggesting a lowered risk for cervical cancer development.
Similar findings have been observed in other countries, such as England, where vaccination programs have led to an estimated 83.9% reduction in cervical cancer incidence and a 94.3% decrease in high-grade cervical intraepithelial neoplasia (CIN3) in vaccinated cohorts. The US has also reported around a 65% reduction in cervical cancer rates among young women due to widespread HPV vaccination.
These findings underscore the HPV vaccine's ability to prevent infection with the most oncogenic HPV types, thereby substantially reducing the incidence of cervical cancer and precancerous lesions. The Robert Koch Institute (RKI), a German federal institution for disease control and prevention, reports that about half of all infection-related cancers worldwide are caused by HPV.
HPV, among the most common sexually transmitted infections globally, is the cause of many infection-related cancers worldwide, including cervical, penile, anal, and cancers in the mouth and throat area. It is assumed that women who were vaccinated against Human Papillomaviruses as children have a significantly lower risk of developing cervical cancer than unvaccinated women.
Two vaccinations, at least five months apart, are necessary for protection against HPV. In Denmark, the vaccination rate for 14-year-old girls is 60%, and for 13-year-old boys, it is 25%. In Germany, the HPV vaccine has been recommended for girls since 2007 and for boys since 2018, aged 9 to 14.
Despite the promising results, it's important to note that depending on the virus type, an HPV infection may have no consequences and go unnoticed. However, the prevention of cervical cancer and other HPV-related cancers through vaccination is a significant step forward in disease control and prevention efforts.
[1] The Danish study: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.30.2200630 [2] English study: https://www.bmj.com/content/370/bmj.m1638 [3] US study: https://www.cdc.gov/mmwr/volumes/70/wr/mm7005a2.htm
- The effectiveness of HPV vaccination in reducing cervical cancer cases is supported by a groundbreaking study published in "Eurosurveillance."
- Conducted over seven years, the study analyzed around 17,000 Pap smears from 8,659 women in Denmark.
- HPV types 16 and 18, responsible for about 74% of cervical cancers pre-vaccination, have nearly been eliminated in Denmark since 2008.
- The study shows a significant reduction in HPV prevalence and persistent infection among vaccinated women, lowering the risk for cervical cancer development.
- Similar findings have been observed in countries like England and the US, where vaccination programs have led to reduced cervical cancer incidence and precancerous lesions.
- The Robert Koch Institute reports that half of all infection-related cancers worldwide are caused by HPV.
- HPV is the primary cause of many infection-related cancers globally, including cervical, penile, anal, and cancers in the mouth and throat area.
- Vaccination is assumed to significantly lower the risk of developing cervical cancer for girls who were vaccinated against Human Papillomaviruses as children.
- Two vaccinations, at least five months apart, are necessary for protection against HPV.
- In Denmark, the vaccination rate for 14-year-old girls is 60%, and for 13-year-old boys, it is 25%.
- In Germany, the HPV vaccine has been recommended for girls since 2007 and for boys since 2018, aged 9 to 14.
- An HPV infection may have no consequences and go unnoticed, depending on the virus type.
- The prevention of cervical cancer and other HPV-related cancers through vaccination is a significant step forward in disease control and prevention efforts.
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