Side Effects of Gocovri: Detailing Their Nature and Coping Strategies
In a recent development, patients and healthcare professionals should be aware of the serious side effects associated with the Parkinson's disease treatment Gocovri (amantadine extended release). While the medication is effective in managing involuntary movements, it has been linked to several adverse reactions, including hallucinations and orthostatic hypotension.
Hallucinations, a disturbance in a person's perception of reality, have been identified as a relatively common serious side effect of Gocovri. The medication ranks higher in causing hallucinations compared to other anti-dyskinetic drugs, according to a network meta-analysis using SUCRA scores[1]. This implies that hallucinations are a relatively frequent occurrence with Gocovri.
Orthostatic hypotension, a condition characterised by a drop in blood pressure when standing or sitting up too quickly, is another recognised side effect associated with Gocovri. While less frequent than hallucinations, this condition can lead to symptoms such as dizziness, lightheadedness, blurred vision, fainting, and falls, which are significant safety concerns for Parkinson's patients[2].
Additional serious neurological side effects, including confusion, delirium, and psychiatric symptoms, have also been noted with Gocovri. These side effects may relate to or coexist with hallucinations[1][2].
Exact numeric incidence rates for these specific side effects with Gocovri were not found in the current search results. However, it is established that hallucinations and hypotension are known serious adverse effects. Patients receiving Gocovri should be monitored for these side effects, particularly elderly or those with predisposing conditions.
Common side effects of Gocovri include dry mouth, constipation, dizziness, peripheral edema, nausea, headache, decreased appetite, eye problems, fatigue, difficulty sleeping, muscle spasms, mottled skin, urinary tract infection, and mild allergic reactions. Mild side effects may be temporary but can last longer, become severe, or bother the patient, in which case they should consult a doctor or pharmacist.
To reduce the risk of worsening orthostatic hypotension side effects, it is advisable to avoid alcohol. Drinking plenty of fluids and standing up slowly can also help prevent these symptoms. If you experience lightheadedness, fainting, or frequent falls, consult your doctor for additional ways to minimise this side effect.
Gocovri comes as an extended-release oral capsule. However, it may not be safe for use during pregnancy or breastfeeding. If you have a history of psychosis or psychotic disorder, impulsive behaviours or urges, depression or suicidal thoughts, or a history of allergic reactions, discuss these with your doctor before starting Gocovri treatment.
The FDA tracks and reviews side effects of medications after they are approved, and individuals can report side effects experienced while taking Gocovri to the FDA through MedWatch.
Gocovri (amantadine) is a brand-name medication used to treat involuntary movements in adults with Parkinson's disease. While the medication offers significant benefits, it is crucial for patients and healthcare professionals to be aware of its potential risks to ensure safe and effective treatment.
[1] Network meta-analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881706/ [2] Amantadine prescribing information: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022434s048lbl.pdf
- Given the link between Gocovri and hallucinations, it's essential for both patients and healthcare professionals to be cognizant of this neurological disorder, as it ranks higher in occurrence among anti-dyskinetic drugs.
- In addition to hallucinations, Gocovri has been shown to cause confusion, delirium, and psychiatric symptoms, which may escalate the already serious side effects associated with the medication.
- Pharmacists and medical-professionals should emphasize the importance of monitoring patients receiving Gocovri, particularly the elderly or those with predisposing conditions, to prevent or manage serious health-and-wellness issues linked to the drug.
- With Gocovri being effective in managing Parkinson's disease symptoms, patients must be aware of other less common side effects, such as orthostatic hypotension, which can manifest as symptoms like dizziness, fainting, and falls.
- As science and medicine evolve, it's crucial that we continue monitoring drugs like Gocovri and report reported side effects to scientific bodies, such as the FDA's MedWatch program, to ensure the safety and well-being of patients managing neurological disorders like Parkinson's disease.
