Xermelo's Potential Adverse Reactions and Management Strategies
Xermelo, a medication used to treat carcinoid syndrome in adults, can have various side effects. Here's what you need to know about them.
Xermelo can cause common side effects such as nausea, headache, elevated liver enzymes, peripheral edema (swelling of the arms, legs, hands, and feet due to fluid buildup), depression, and mild side effects like flatulence, reduced appetite, fever, abdominal pain or swelling, mild constipation, and skin rash.
Less common side effects of Xermelo include severe cutaneous adverse reactions (SCARs), ocular toxicities, diarrhea, muscle or joint pain, and facial and peripheral swelling. SCARs are rare but serious allergic skin reactions, while ocular toxicities may manifest as blurry vision, redness, eye pain, excessive tearing, light sensitivity, or foreign body sensation. Diarrhea can occur, sometimes requiring dietary modification and medication. Muscle or joint pain may need symptomatic treatment, and fluid accumulation sometimes affecting the face, especially around the eyes, warrants medical assessment.
Xermelo can also cause serious side effects such as depression and severe constipation. Depression was a common side effect reported in Xermelo's clinical trials. If you experience new or worsening symptoms of depression, talk with your doctor. They can recommend ways to manage this side effect, such as talk therapy or antidepressant medication.
Constipation can occur, and constipation was reported commonly in Xermelo's clinical trials. If you experience constipation during treatment, tell your doctor. Depending on the severity of your symptoms, your doctor may prescribe medication to treat this side effect or recommend pausing Xermelo treatment until your symptoms ease.
Severe constipation can lead to complications, such as an intestinal blockage or tear. Symptoms of these conditions include severe, persistent, or worsening abdominal pain and swelling. If you experience such symptoms, seek immediate medical attention by calling 911 or your local emergency number.
It's important to note that Xermelo may not be the right treatment option for everyone. People with certain medical conditions or other factors that affect their health should discuss this with their doctor before starting treatment. These conditions and factors to consider include liver problems, dialysis for kidney failure, allergic reaction to Xermelo or any of its ingredients, pregnancy, breastfeeding, and alcohol consumption.
If you have questions about drinking alcohol during treatment with Xermelo, talk with your doctor. Alcohol consumption can worsen symptoms of carcinoid syndrome, which Xermelo is prescribed to treat.
The Food and Drug Administration (FDA) tracks and reviews side effects of medications. Sharing your experience with Xermelo's side effects can help make medications safer for everyone. To report side effects, visit MedWatch or call 800-FDA-1088.
For mild symptoms of an allergic reaction, call a doctor right away. For severe allergic reaction symptoms, seek immediate medical attention by calling 911 or your local emergency number.
If you'd like to learn more about Xermelo, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.
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